Donor Management

A large burden of undiagnosed hepatitis virus causes remains globally. Despite the 257 million people living with chronic hepatitis B virus infection, and 71 million with chronic viraemic HCV infection, most people with hepatitis remain unaware of their infection. When a patient progresses towards chronic conditions, there is a 25-40% chance (Hep C only) of liver cirrhosis and a 60% chance (Hep C only) of hepatocellular carcinoma (HCC).

HCC is the 6th most common cancer in the world and the 3rd leading cause of death from cancer. Two-thirds of these deaths are caused by hepatitis and HCC related to Hepatitic C infection is the fastest rising cause of cancer-related deaths. The drive towards hepatitis elimination is not only about detection and diagnosis but also the linkage to care that can be improved with fast innovative technologies to manage progression towards cancer.

Solutions

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M2BPGi – Novel serum marker for assessing Liver Fibrosis

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M2BPGi – Novel serum marker for assessing Liver Fibrosis

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Viral Hepatitis – Innovation in Hepatitis C Testing

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Viral Hepatitis – Innovation in Hepatitis C Testing

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Applications

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Diagnosis of Liver Fibrosis With Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein (WFA-M2BP) Among Chronic Hepatitis B Patients

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Diagnosis of Liver Fibrosis With Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein (WFA-M2BP) Among Chronic Hepatitis B Patients

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Jekarl, Choi, Lee, Kwon, Lee, Yu, … Yoon. (2018). Annals of Laboratory Medicine, 38(4), 348–354
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Diagnostic performance of Mac‐2 binding protein glycosylation isomer (M2BPGi) in screening liver fibrosis in health checkups.

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Diagnostic performance of Mac‐2 binding protein glycosylation isomer (M2BPGi) in screening liver fibrosis in health checkups.

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Nah, Eun‐Hee, et al. Journal of Clinical Laboratory Analysis (2020).
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Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis

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Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis

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Shirabe et al. (2018). Journal of Gastroenterology, 1–8.
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Role of serum M2BPGi levels on diagnosing significant liver fibrosis and cirrhosis in treated patients with chronic hepatitis B virus infection

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Role of serum M2BPGi levels on diagnosing significant liver fibrosis and cirrhosis in treated patients with chronic hepatitis B virus infection

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Mak, Lung-Yi, Danny Ka-Ho Wong, Ka-Shing Cheung, Wai-Kay Seto, Ching-Lung Lai, and Man-Fung Yuen. Clinical and translational gastroenterology. 2018 Jun;9(6)
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Sequential Combination of FIB-4 Followed by M2BPGi Enhanced Diagnostic Performance for Advanced Hepatic Fibrosis in an Average Risk Population

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Sequential Combination of FIB-4 Followed by M2BPGi Enhanced Diagnostic Performance for Advanced Hepatic Fibrosis in an Average Risk Population

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Kim, Mimi, et al. Journal of Clinical Medicine 9.4 (2020): 1119
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Usefulness of Mac-2 binding protein glycosylation isomer in non-invasive probing liver disease in the Vietnamese population.

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Usefulness of Mac-2 binding protein glycosylation isomer in non-invasive probing liver disease in the Vietnamese population.

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Pham TTT, Ho DT, Nguyen T. World J Hepatol 2020; 12(5): 220-229
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Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein and type 4 collagen 7S: useful markers for the diagnosis of significant fibrosis in patients with non‐alcoholic fatty liver disease

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Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein and type 4 collagen 7S: useful markers for the diagnosis of significant fibrosis in patients with non‐alcoholic fatty liver disease

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Ogawa, Honda, Kessoku, Tomeno, & Imajo. (2018). Journal of Hepatology