Speaker   

Dr. Tan Chuen Wen

Consultant, SingHealth Duke-NUS Blood Cancer Centre

Consultant, Haematology, Singapore General Hospital

Visiting Consultant, Department of Pathology, Sengkang General Hospital

Objectives of Lecture

-Learn about the principle of clot waveform analysis (CWA)

-Describe established clinical utility in haemophilia care

– Describe emerging data in prothrombotic conditions and findings in COVID-19 patients

Abstract of Lecture

Clot waveform analysis (CWA) is an extended evaluation of routine clotting tests such as activated partial thromboplastin time and prothrombin time. It is based on the continuous observation of the changes in optical transmittance or absorbance that occur as fibrin is formed in plasma during the performance of these clotting assays. The data obtained therefore reflect the global haemostatic function beyond a single clotting time. CWA has been initially investigated in the diagnosis andprognosis of disseminated intravascular coagulation and sepsis. Many studies subsequently followed in the field of bleeding disorders particularly in the diagnosis and management of Haemophilia A. More recently, data are emerging in the area of prothrombotic conditions. With more automated coagulation analysers having the capability to perform CWA and with increasing pre-analytical and clinical information becoming available, CWA could be a potentially rapid, accessible, inexpensive and easily performed tool for the assessment of various thrombotic and haemostatic disorders.

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