PRODUCTS

Hyphen Reagents

Heparin and Analogues
  • Biophen® Heparin LRT (Liquid Reagent Technology) (Ref 221011/221013) 4 x 7.5 mL/ 3 x 3 mL
    • A chromogenic anti-Xa method for measuring Unfractionated Heparin (UFH) and Low Molecular Weight Heparin (LMWH), using the same calibration curve (kinetics method, one stage). The assay can also be used for testing heparin analogues, such as Sodium Danaparoid (Orgaran®), or Pentasaccharide (Fondaparinux Arixtra®).
  • Biophen® Heparin (Ref 221003/221006) 3 x 3.75 mL/ 4 x 7.5 mL
    • A chromogenic anti-Xa method for measuring Unfractionated Heparin (UFH) and Low Molecular Weight Heparin (LMWH), using the same calibration curve (kinetics method, one stage). The assay can also be used for testing heparin analogues, such as Sodium Danaparoid (Orgaran®), or Pentasaccharide (Fondaparinux Arixtra®).

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Direct Oral Anticoagulants (DOACs)
  • Direct Thrombin Inhibitors
    • HEMOCLOT Thrombin Inhibitors (Ref CK002K/CK002L) 3 x 1 mL/ 3 x 2.5 mL
      • An assay designed for the quantitative measurement of Thrombin Inhibitor (DTI), such as Dabigatran and Argatroban, in human citrated plasma, with a clotting method based on the inhibition of a constant and defined concentration of thrombin. Measuring DTI concentrations in patient’s plasma may be used as an aid in the management of patients receiving DTIs who are suspected of having excess anticoagulant activity.
    • Biophen® DTI (Ref 220202) 2 x 2.5 mL
      • BIOPHEN DTI kit is a quantitative assay for measuring the anti-IIa activity of hirudin and other Direct Thrombin Inhibitors (DTIs) in human citrated plasma, using a chromogenic method, manual or automated.
  • Direct Factor Xa Inhibitors
    • Biophen® DiXal (Ref 221030) 3 x 2.5 mL
      • A quantitative assay for measuring the Direct Factor Xa Inhibitor (DiXaI), such as Rivaroxaban and Apixaban in human citrated plasma, using a chromogenic method.

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Platelet aggregation
  • ADP (Ref AG001K) 200 µM
    • Investigation of platelet aggregation induced by ADP.
  • Epinephrine (Ref AG002K) 1 mM
    • Investigation of platelet aggregation induced by Epinephrine.
  • Arachidonic Acid (Ref AG003K) 15mM
    • Investigation of platelet aggregation induced by Arachidonic Acid.
  • Ristocetin (Ref AG004K) 15 mg/mL
    • Measurement of the von Willebrand Factor Ristocetin cofactor by platelet aggregation.
  • Collagen (Ref AG005K) 1 mg/mL
    • Investigation of platelet aggregation induced by Collagen.
  • Lyophilized platelets (Ref AG006A/AG006K) 1 x 5 mL/ 3 x 5 mL
    • Quantitative determination of von Willebrand Factor (vWF) in human plasma through its Ristocetin cofactor activity, by using lyophilized platelets and ristocetin.

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Calibrators
  • Heparin 
    • Biophen® Heparin Calibrator (Ref 222001) 4 for 5 x 1mL
      •  A set of calibration plasmas for Heparin (UFH and LMWH) measurements, using anti-Xa colorimetric assays, with 5 levels at about 0, 0.4, 0.8, 1.20 and 1.60 IU/mL.
    • Biophen® UFH Calibrator (Ref 222301) 4 for 5 x 1mL.
      • A set of calibration plasmas for Unfractionated Heparin (UFH) measurements, using anti-Xa colorimetric assays, with 5 levels at about 0, 0.35, 0.70, 1.05, 1.40 IU/mL
  • Direct Thrombin Inhibitors
    • Dabigatran Plasma Calibrator (Ref 222801) 4 for 3 x 1mL
      • A set of calibration plasmas for Dabigatran measurements, titrated and optimised using the anti-IIa clotting assay, such as HEMOCLOT Thrombin Inhibitors (Ref CK002K/CK002L).
    • BIOPHEN® Dabigatran Calibrator Low (Ref 222901) 4 for 3 x 1mL
      • A set of calibration plasmas for Dabigatran measurements, titrated and optimised using the anti-IIa clotting assay, such as HEMOCLOT Thrombin Inhibitors (Ref CK002K/CK002L). High sensitivity for accurate measurement of the residual concentration.
  • Direct Factor Xa Inhibitors
    • Biophen® Rivaroxaban Plasma Calibrator (Ref 222701) 4 for 3 x 1mL
      • A set of calibration plasmas for Rivaroxaban measurements, titrated and optimized for anti-Xa colorimetric assays, such as Biophen® DiXaI (Ref221030) and Biophen® Heparin (LRT) (Ref 221011/221013).
    • Biophen® Rivaroxaban Calibrator Low (Ref 226001) 4 for 3 x 1mL
      • A set of calibration plasmas for Rivaroxaban measurements, titrated and optimised for anti-Xa colorimetric assays, such as Biophen® DiXaI(Ref 221030) and Biophen® Heparin (LRT) (Ref 221011/221013).
    • Biophen® Apixaban Calibrator (Ref 226201) 4 for 3 x 1 mL
      • A set of human plasmas supplemented with Apixaban and lyophilized. They are titrated and optimised for anti-Xa chromogenic assays, such as Biophen® DiXaI and Biophen® Heparin (LRT).
    • Biophen® Apixaban Calibator Low (Ref 226101) 4 for 3 x 1 mL
      • A set of human plasmas supplemented with Apixaban and lyophilized. They are titrated and optimized for anti-Xa chromogenic assays, such as Biophen® DiXaI (Ref 221030) and Biophen® Heparin (LRT) (Ref 221011/221013). High sensitivity for accurate measurement of the residual concentration.

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Controls
  • Heparin
    • Biophen® LMWH Control Plasma (Ref 223001), 6 for 2 x 1mL 
      • A set of control plasmas for the quality control of Low Molecular Weight Heparin (LMWH) measurements, using anti-Xa colorimetric assays, with 2 levels at about 0.80 and 1.20 IU/mL.
    • Biophen® LMWH Control C3 (Ref 223801), 12x1mL
      • A set of control plasmas for the quality control of Low Molecular Weight Heparin (LMWH) measurements, using anti-Xa colorimetric assays, with level at about 0.80 IU/mL.
    • Biophen® LMWH Control C4 (Ref 224201), 12x1mL
      • A set of control plasmas for the quality control of Low Molecular Weight Heparin (LMWH) measurements, using anti-Xa colorimetric assays, with level at about 1.20 IU/mL.
    • Biophen® LMWH Control Low (Ref 223701)
      • A set of control plasmas for the quality control of Low Molecular Weight Heparin (LMWH) measurements, using anti-Xa colorimetric assays, with 2 levels at about 0.25 and 0.50 IU/mL.
    • Biophen® LMWH Control Low CI (Ref 224301) 12x1mL
      • A set of control plasmas for the quality control of Low Molecular Weight Heparin (LMWH) measurements, using anti-Xa colorimetric assays, with level at about 0.25 IU/mL.
    • Biophen® LMWH Control Low CII (Ref 224401) 12x1mL
      • A set of control plasmas for the quality control of Low Molecular Weight Heparin (LMWH) measurements, using anti-Xa colorimetric assays, with level at about 0.50 IU/mL.
    • Biophen® UFH Control Plasma (Ref 223101) 6 for 2 x 1 mL
      • A set of control plasmas for the quality control of Unfractionated Heparin (UFH) measurements, using anti-Xa colorimetric assays, with 2 levels at about 0.20 and 0.50 IU/mL.
    • Biophen® UFH Control C1 (Ref 224101) 12×1 mL
      • A set of control plasmas for the quality control of Unfractionated Heparin (UFH) measurements, using anti-Xa colorimetric assays, with level at about 0.20 IU/mL.
    • Biophen® UFH Control C2 (Ref 223901) 12×1 mL
      • A set of control plasmas for the quality control of Unfractionated Heparin (UFH) measurements, using anti-Xa colorimetric assays, with level at about 0.50 IU/mL.
  • Direct Thrombin Inhibitors
    • Dabigatran Control Plasma (Ref 224701) 6 for 2 x 1 mL
      • A set of control plasmas for the quality control of dabigatran measurements, using anti-IIa clotting assay (standard range). This kit is optimized for use with the HEMOCLOT Thrombin Inhibitor assay (Ref CK002K/CK002L).
    • Biophen® Dabigatran control Low (Ref 225001) 6 for 2 x 1mL
      • A set of 2 levels control plasmas lyophilised and spiked with Dabigatran. They are titrated and optimized for anti-IIa clotting assays (low range), such as HEMOCLOT Thrombin Inhibitors assay.
  • Direct Factor Xa Inhibitors
    • Biophen® Rivaroxaban Control Plasma (Ref 224501) 6 for 2 x 1 mL
      • A set of control plasmas for the quality control of Rivaroxaban® measurements in standard range, using anti-Xa colorimetric assays, such as Biophen® DiXaI (Ref 221030) or Biophen® Heparin LRT (Ref 221011/221013).
    • Biophen® Rivaroxaban Control Low (Ref 225101) 6 for 2 x 1 mL
      • A set of 2 levels control plasmas lyophilised and spiked with Rivaroxaban®. They are titrated and optimized for anti-Xa chromogenic assays (Low range), such as Biophen® DiXaI (Ref 221030) or Biophen® Heparin LRT (Ref221011/221013).
    • Biophen® Apixaban Control (Ref 225301) 6 for 2 x 1 mL
      • A control plasmas supplemented with Apixaban at 2 different levels, and lyophilized. They are titrated and optimized for anti-Xa chromogenic assays (standard range), such as Biophen® DiXaI (Ref 221030) or Biophen® Heparin (LRT) (Ref 221011/221013).
    • Biophen® Apixaban Control Low (Ref 225201) 6 for 2 x 1 mL
      • A control plasmas supplemented with Apixaban at 2 different levels, and lyophilized. They are titrated and optimised for anti-Xa chromogenic assays (low range), such as Biophen® DiXaI (Ref 221030) or Biophen® Heparin (LRT)(Ref 221011/221013).

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